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Gadolinium diethylenetriamine pentaacetic acid(DTPA)enhanced magnetic resonance imaging was performed in eight patients with Cushing disease and surgically proven pituitary microadenomas.A 1.5 T scanner was used with 3 mm contiguous slices.Short repetition times(TR),short echo times(ET),and long TR,long TE sequences were obtained before and serially after intravenous administration of Gd-DTPA.Three of eight(38%)microadenomas were undetectable both without and with Gd-DTPA:one post-Gd-DTPA scan was false positive on the side opposite the adenoma.Hemihypophysectomy based on a petrosal sinus adrenocorticotropic hormone(ACTH)gradient cured all three patients.Two microadenomas(25%)were visible as hypointense foci following Gd-DTPA but not on unenhanced scans.The remaining three microadenomas(38%)were seen before and after Gd-DTPA on T1-weighted images.In this small series of ACTH-producing microadenomas,one-third were seen on unenhanced 1.5 T scans,one-third were seen only after Gd-DTPA,and one-third were not imaged even with Gd-DTPA enhancement. |
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gadolinium
MRI
MRI,abnormal
neoplasm,pituitary
pituitary,adenoma
pituitary,microadenoma
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